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In the tissues, CO 2 enters the erythrocyte by diffusion, where it is hydrated with the help of carbonic anhydrase

(2020) 53:e12761

[27] The connection between GSTP inhibition of the pro-apoptotic JNK pathway and the isozyme's overexpression in drug-resistant tumor cells may itself account for the tumor cells' ability to escape apoptosis mediated by drugs that are not substrates of GSTP

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In cancer (Table 1), CDO1 is usually silenced by promoter methylation and this is associated with poor prognosis, 70,74 implying that the shutting down of CDO1 expression favours cancer progression