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[62]) carried out a phase 1 study with 47 healthy participants without diabetes participants receiving single ascending dose of retatrutide (0.1, 0.3, 1, 3, 4.5, or 6 mg) versus placebo

18 GLP-2, also secreted by enteroendocrine L-cells, differs from GLP-1 and GIP in that it appears to have less influence on metabolic control and primarily functions as an intestinotrophic factor, helping maintain intestinal health

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Tirzepatide is a medication that targets two hormones: GIP and GLP-1

Lastly, in hypertension-prone animal models, GLP-1 infusion exerted its diuretic and natriuretic effects and resulted in a reduction of hypertension and albuminuria development, and an improved endothelial function [23]