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Mice exposed to altered light-dark cycles also exhibited disrupted Per2 rhythms alongside chronic inflammation characterized by elevated IL-1, IL-6, and TNF-, and changes in macrophage populations favoring pro-inflammatory phenotypes 126,202

Importantly, NAD + was systemically lowered, detectable in the blood of the patients

100-190 min per session

Abbreviations BAL: Bronchoalveolar lavage BALF: Bronchoalveolar lavage fluid COPD: chronic obstructive pulmonary disease CS: cigarette smoke CSE: cigarette smoke extract ELF: epithelial lining fluid GSH: glutathione References Pryor WA, Stone K: Oxidants in cigarette smoke

Yersin B, Nicolet JF, Dercrey H, Burnier M, van Melle G, Pcoud A