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Metrnl-specific overexpression or recombinant Metrnl administration in the kidney regulates renal tubular lipid metabolism through mitochondrial homeostasis mediated by the Sirtuin 3(Sirt3)-AMPK/uncoupling protein 1(UCP1) signaling axis, alleviates renal injury, and delays DKD in diabetic mice (193)
Many patients taking GLP-1 drugs are already on multiple medications to lower high blood pressure
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The study indicates that LNPs could be employed as drug delivery vehicles to transfer genes across the blood-brain barrier (178)
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