Side-by-Side Comparison FDA Approved Tesamorelin Yes (Egrifta, 2010) CJC-1295/Ipamorelin No (compounded) Tesamorelin/Ipamorelin No (compounded combo) Mechanism Tesamorelin GHRH receptor (single pathway) CJC-1295/Ipamorelin GHRH + ghrelin receptor (dual pathway) Tesamorelin/Ipamorelin GHRH + ghrelin (FDA molecule + dual pathway) Half-Life Extension Tesamorelin DPP-IV protection (~26 min) CJC-1295/Ipamorelin Enzyme-resistant substitutions (~30 min, no-DAC) Tesamorelin/Ipamorelin DPP-IV protection + ghrelin receptor Clinical Evidence Tesamorelin 2 Phase 3 RCTs, 816 patients CJC-1295/Ipamorelin Phase 2 (CJC-1295) Tesamorelin/Ipamorelin Individual components well-studied Fat Loss Data Tesamorelin 15% visceral fat reduction (CT-measured) CJC-1295/Ipamorelin Body composition improvement (practitioner data) Tesamorelin/Ipamorelin Combined mechanisms Liver Fat Tesamorelin 35% normalized liver fat (Lancet HIV, 2019) CJC-1295/Ipamorelin Not specifically studied Tesamorelin/Ipamorelin Tesamorelin component covers this Sleep Benefit Tesamorelin Moderate CJC-1295/Ipamorelin Strong (dual-pathway overnight GH) Tesamorelin/Ipamorelin Strong Regulatory Pedigree Tesamorelin Strongest (current FDA approval) CJC-1295/Ipamorelin Standard compounded Tesamorelin/Ipamorelin FDA molecule + compounded Tesamorelin: The FDA-Approved Option Tesamorelin has the strongest clinical evidence of any growth hormone peptide
Increlex labeling notes rapid increases in renal and splenic length in some treated patients
1 Effectiveness Semaglutide has been evaluated as a single treatment and as additional treatment for patients already being treated with metformin, a sulfonylurea, or long-acting insulin in seven clinical trials enrolling more than 8,400 patients
doi: 10.1038/s41467-018-03941-2 34 ThompsonAKanamarlapudiV
During her career Laura has tried and tested thousands of products, interviewed some of the biggest celebrities and industry experts, and travelled all over the world to write travel features.
