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Am J Health Syst Pharm (2016) 73(19):1493507

These findings provide a basis for the use of metabolomic reprogramming as a strategy to restore antibiotic susceptibility in resistant bacteria

TMAO not only induces endothelial dysfunction but also acts on various cell types, such as endothelial cells, epithelial cells, vascular smooth muscle cells, nerve cells, and pancreatic cells, triggering multiple cell death mechanisms, including necrosis and programmed cell death, thereby influencing host health