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Draznin B, Aroda VR, Bakris G et al (2022) 7

41,42 GLP-1R is expressed in the cardiovascular system, and its knockout has implications for cardiovascular function

Jan 16, 2026 11 min read IN THIS ARTICLE KEY TAKEAWAYS Weight loss includes both fat and muscle loss, not just fat

Increased risk of heart failure hospitalization with GLP-1 receptor agonists in patients with reduced ejection fraction: a meta-analysis of the EXSCEL and FIGHT trials