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This is because exercise stimulates muscle growth but this process can only happen if you have an adequate supply of protein. If you cut back too drastically on your food intake, especially protein, your body will break down muscle for fuel

6 Blood sugar and insulin sensitivity Human trials demonstrate that berberine can lower blood sugar and improve insulin sensitivity in people with type 2 diabetes, with effects comparable to conventional oral medications

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Yes, THC in cannabis commonly increases appetite ("the munchies"), which may counteract tirzepatide's appetite-suppressing effects and lead to increased caloric intake, potentially compromising weight management goals