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Support groups or counseling may also help those with severe phobias

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For a detailed description please refer to the Supplementary methods

6 However, unlike SGLT-2i, liraglutide did not significantly reduce the incidence of hospitalization for patients with heart failure, which was a predominant benefit with empagliflozin, 48 although the drug was associated with delayed cardiovascular benefits, possibly due to the modification of progression of atherosclerotic cardiovascular disease

For patients who are not well-controlled on a treatment with metformin and basal insulin, a treatment intensification with a DPP-4 inhibitor may be feasible