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10.1212/WNL.0000000000000610 Neurology 34 ChoudharyR.KumarM.KatyalA

Research using MT-1 in cell systems expressing MC1R variants associated with red hair and fair skin has characterised reduced cAMP signalling responses, impaired MITF activation, and decreased melanogenesis , documenting the functional consequences of loss-of-function MC1R polymorphisms at the receptor signalling level and establishing the molecular basis for the reduced photoprotective melanogenesis capacity associated with these variants

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