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To further determine the role of IPA in the protection against IBD, groups of wild-type C57BL/6 J mice (WT B6) were administrated IPA through two distinct regiments according to previously published literatures: (1) daily oral gavaged with 200 mg/kg or 20 mg/kg IPA for 5 days, or (2) ad libitum access to drinking water containing 200 g/mL IPA for 14 days (approximately equivalent to 33 mg/kg/day), and then administered DSS for colitis induction (Supplementary Fig

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