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By targeting inflammation and reducing pain signals, Toradol helps quell the intense pain associated with migraines

doi:10.1016/j.dsx.2020.07.031

The predominant isoform is the NOX2 in brain endothelial cells, and it has been observed that the Nox2- knockout mice induce less MMP-9 and diminished expression of occludin, a critical protein of the BBB permeability (Liu et al., 2011)