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For semaglutide, the main concerns include pancreatitis (rare but documented), gallbladder events (including gallstones, particularly during rapid weight loss), and a theoretical concern about medullary thyroid carcinoma based on rodent studies
Body size matters
2013;2:227232.pmc.ncbi.nlm.nih.gov Alfredson H et al
Microscopy Tissue specimens from liver, spleen, stomach, duodenum, ileum, cecum, ascending colon, cecum, lungs and heart were obtained from rats with suprahepatic occlusion of the inferior vena cava at 15 min, 24 h and 48 h post-ligation
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