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The Mediterranean approach works exceptionally well for GLP-1 diets

Trends Food Sci Technol 69:157171

In both in vitro (human neuroblastoma SH-SY5Y cells) and in vivo (PSAPP-Tg: double transgenic mice expressing chimeric mouse/human amyloid precursor protein and mutant human presenilin 1 directed to CNS neurons), catalpol alleviates Alzheimers disease progression by promoting the level of miR-138-5p in exosomes secreted by neural stem cells (Meng S

In the US the drug was approved in 2023 to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visits in patients with heart failure or type 2 diabetes mellitus, chronic kidney disease, and other cardiovascular risk factors

doi: 10.1016/j.atherosclerosis.2006.12.019