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GLP-1s are most effective when combined with healthy eating and regular exercise

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While consensus does not exist regarding the exact synergistic mechanisms by which dual-agonists work, the addition of GIP agonism is posited to improve the HbA1c control and weight loss offered by GLP-1 agonists alone by enhancing insulin secretion, decreasing energy consumption, and stimulating satiety in the hypothalamus

Success starts with ongoing insulin use, careful monitoring, education and regular communication with your healthcare team

Obesity (Silver Spring) 2023;31(1):96110