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Pancreatic cancer has received particular attention due to the pancreatic expression of GLP-1 receptors and early concerns about pancreatitis potentially increasing cancer risk

Some patients may experience persistent mild bloating that becomes their "new normal" on therapy

Focus on high-protein foods, as eating large amounts of carbohydrates will negatively impact blood sugars

A 2024 study found that patients taking semaglutide medications were significantly more likely to develop NAION compared to certain other diabetes medications, raising concern about a possible association between GLP-1 drugs and optic nerve injury