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Clinical evidence The effectiveness of combination therapy with PIO (1530 mg daily) and tofogliflozin (TOFO 20 mg daily) for 24 weeks was investigated in 32 patients who experienced T2D and NAFLD in an open-label RCT [116]

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110 Cardiovascular disturbances, chronic heart failure, pulmonary hypertension, and arrhythmias appear as a particular point of counteraction, much like the disturbances after hypokalemia and hyperkalemia, 41 - 45 and potassium-cell membrane dysfunction or complex muscle disorders produced by potassium 43 - 45 or magnesium overload, 111 or pupil paralysis with atropine

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