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The rationale is that the two medications work through completely different mechanisms, phentermine through norepinephrine release and semaglutide through GLP-1 receptor activation, so they could theoretically complement each other

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Ozempic and semaglutide are related, as Ozempic contains the active ingredient liraglutide, which is a type of GLP-1 analogue

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The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: A new role for mesolimbic GLP-1 receptors

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