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In the present study, we compared the effects of TDDS and the injectable administration of semaglutide on body weight, fat distribution, metabolic rate, organ function, and behaviors in C57BL/6J male mice

Br J Clin Pharmacol 1998;46:10110

Patients and physicians both consistently report that waist and abdominal measurements shift noticeably, even before total weight loss looks dramatic on the scale