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Research at authors' laboratories is financed by grants PI12/00241, PI12/00324, and RETICS RD12/0013/0002 from Fondo de Investigacin Sanitaria, Instituto de Salud Carlos III, Spain, Innovation and GR10068 from Junta de Extremadura, Spain

IGF-LR3 1MG Research-Grade Growth Factor Analog IGF-LR3 1MG (Insulin-like Growth Factor Long R3) is a lab-grade version of IGF-1

Ethics declarations Conflict of interest There is no conflict of interest in this study

Severity of BED was determined based on having at least 3 binge days per week for 2 weeks prior to the baseline visit and on having a Clinical Global Impression Severity (CGI-S) score of 4 at the baseline visit

HD declares no conflicts of interest