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MOTS-c Dosage Chart MOTS-c research-planning dose tiers Tier Lower-end starting tier Dose 5 mg Frequency 2x per week Cycle length 4 weeks Notes Used by researchers checking tolerance and histamine response

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Acknowledgements Medical Writing/Editorial Assistance The authors would like to acknowledge Victoria Jeter, PhD, of PRECISIONscientia in Yardley, Pennsylvania for medical writing support, as well as Ryan Ross, MS, of Merative LP in Cambridge, Massachusetts for statistical consulting support, which was funded by Novo Nordisk Inc