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What We Aim To Do: Optimize the function of the "Sleeping Zone" (Penumbra)

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This is where the strongest preclinical signal is, and where injectable community reports are most consistent

The different hGSTP1-1 mutants show slightly altered regioselectivities in the formation of the individual GSH conjugates of clozapine which suggests that the binding orientation of the reactive nitrenium ion of clozapine is affected by the mutations [34]