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August 2025 : The US FDA approved Wegovy (semaglutide 2.4 mg) for the treatment of noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH) in adults with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis), in combination with a reduced-calorie diet and increased physical activity

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As a D-amino acid peptide, FOXO4-DRI is costly to synthesize, and a wrong amino acid at the binding site can sharply cut activity

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