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The product is likewise indicated for increased physiologic demand (pregnancy, thyrotoxicosis, chronic hemorrhage), for drug-induced depletion, and for select neurologic or hematologic disorders in which B12 plays a pivotal metabolic role

Vasodilation of cerebral blood vessels from GIP receptor activation in the hypothalamus may also play a role in early-treatment headache onset

Adequate protein intake helps preserve lean muscle mass during weight loss, though patients with kidney disease should discuss protein targets with their healthcare provider

Patients should take their medication as prescribed and follow their doctors instructions to discontinue if needed

Many patients on weight-loss protocols are also working toward liposuction for men or a planned abdominoplasty, and clean eating during medication onset directly supports those longer-term goals