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The pattern is less pronounced than melanotan-2 in community reports

doi: 10.1038/nchembio.2079 38 WuZGengYLuXShiYWuGZhangMet al

They synthesized it so we can use it as a targeted therapy

In vivo experiments further support these findings

FDA APPROVES HIGH-DOSE WEGOVY March 2026 The new 7.2 mg dose is triple the previous highest dose of 2.4 mg The issue: Average weight loss with the highest dose of Wegovy is 13% to 16%, while its main competitor, Zepbound, has a mean weight loss of 20% to 22% at its highest dose Why this matters: A study comparing Wegovy doses of 2.4 mg and 7.2 mg found that the higher dose caused more weight loss, but also more gastrointestinal side effects and dysaesthesia