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As GLP-1R agonists mediate their appetite-reducing effects within the central nervous system, the trafficking phenotype of exendin-phe1 could result in reduced brain penetration, mitigating against presumed advantageous effects on neuronal GLP-1R desensitization

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2 Therefore, the focus must be on using the medication period as a catalyst to build robust dietary patterns, consistent exercise routines, mindful eating skills, and healthy coping mechanisms that can support weight maintenance and overall health long after the medication's direct effects may have waned

In federal court, GLP-1 gastrointestinal claims are still consolidated in MDL No