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ROS scavenging and detoxification The antioxidant capacity of GSH derives from its thiol group, which confers potent reducing activity toward ROS, including superoxide anions and H 2 O 2 88

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Even excess of insulin, GH, IGF-I and IGF-II signaling are associated with severe metabolic disease and excess growth and/or obesity

Metformin for liver cancer prevention in patients with type 2 diabetes: a systematic review and meta-analysis

The prevailing model for NRF2-dependent target gene expression involves the binding of NRF2 to ARE sequences within proximal promoters of specific target genes (Tonelli et al, 2018)