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The possible cardioprotective mechanisms of GLP-1 RAs include reducing epicardial fat tissue thickness, preventing activation of the reninangiotensinaldosterone system, improving myocardial energy metabolism, reducing systemic inflammation and cardiac oxidative stress, and delaying the progression of atherosclerosis

doi: 10.1021/ci900508k

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[11] [12] When activated, these receptors trigger several beneficial effects: Enhanced insulin secretion in response to elevated blood glucose levels Suppression of glucagon release , reducing hepatic glucose production Delayed gastric emptying , which promotes satiety and reduces appetite Direct effects on appetite centres in the hypothalamus Commonly prescribed GLP-1 receptor agonists available in the UK include semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and exenatide (Byetta, Bydureon)

doi: 10.2337/db13-1087 105 TurecekPLBossardMJSchoetensFIvensIA