Among those upregulated pathways: collagen synthesis, extracellular matrix remodeling, and growth factor production all critical to maintaining the structural environment hair follicles depend on
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Interestingly, GHK alone appeared to produce a comparable stimulatory action, while copper(II) ions in isolation may indicate no such activity, suggesting the tripeptide moiety may be the primary active component, possibly reforming complexes with trace copper present in the culture medium
Pathological evaluations were conducted by a qualified pathologist from the Graduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung, Taiwan