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Progressive reduction in body weight after treatment with the amylin analog pramlintide in obese subjects a phase 2, randomized, placebo-controlled, dose-escalation study
In particular, the multiple metabolic actions of glucagon highlight the importance of understanding the contributions of individual hormone action to inform the safe, effective and tailored use of GLP-1/glucagon co-agonists to target weight loss and metabolic disease in the future
This targeted delivery supports enzymatic function while minimizing toxicity
Similarly, cutting or modifying patches to adjust dosing is dangerous and should never be attempted, as this can cause rapid, uncontrolled drug release and potential overdose
Campbell KJ, Tait SWG
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