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In studies on cardiovascular diseases, GLP-1RAs have shown potential benefits

Data were extracted into a standardized table capturing Study design, Sample size and population, Intervention or exposure (e.g., antioxidant agent, mitochondrial marker), Outcomes (e.g., pain, fatigue, oxidative markers), Key findings relevant to the PICO questions above

proposed that Ang II expression is associated with mood disorders and that reducing brain Ang II levels might decrease anxiety and depression in animal models ( Table 2 Anxiolytic/anti-depressant effect of RAS blockers