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The 2023 international PCOS guideline confirms letrozole as first-line for ovulation induction, with metformin recommended for adults with PCOS and BMI 25 kg/m for metabolic and anthropometric outcomes

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Researchers found that patients who remained consistent with the once-weekly schedule achieved superior weight loss outcomes compared to historical data on split-dose or variable-interval regimens

This comprehensive strategy has the potential to improve not only glycemic control but also overall cardiovascular health, as excessive weight and high blood sugar are risk factors for heart disease