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Gastroenterology 152 , 16791694.e3 (2017)

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Abnormal function of regulatory lymphocytes, maladaptive training immunity and clonal hematopoiesis of indeterminate potential (CHIP) are the core immune mechanisms, which form a bidirectional association between periodontitis and systemic inflammatory comorbidities such as RA, CAD, AD and type 2 DM (164, 165)