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doi: 10.1016/j.semradonc.2018.10.001 64

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The conserved N-capping box in the hydrophobic core of glutathione S-transferase P1-1 is essential for refolding

So even the topical route, which is the evidence-backed one, should be described as supported by small, sometimes industry-affiliated human cosmetic studies with modest effect sizes, not as proven. The correct posture toward topical GHK-Cu is cautious optimism grounded in real but imperfect human data which is still a materially stronger position than the injectable route can claim