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Tirzepatide did not increase risks of adverse renal events, urinary tract infections, nephrolithiasis (kidney stones), acute kidney injury, or renal cancer compared to placebo, insulin, or other GLP-1 receptor agonists

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The dimerization process involves initial binding of magnesium to the aspartate in the starter sequence which inturn interacts with the pyrophosphate molecule of the thiamine diphosphate through hydrogen bonding [101], followed by one transketolase monomer engaging the pyrophosphate moiety and the other with the thiazolium and pyrimidine rings of ThDP [88, 97]

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