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AUC GIR,0-24h,SS =area under the GIR curve from 0 to 24 hours at steady state

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The KRAS field has evolved rapidly from the first generation of G12C inhibitors to a growing arsenal of G12DRAS(ON), and Pan-RAS strategies

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Evidence supports the efficacy of restrictive diets such as a low histamine diet [9], a low sulfur diet [10], a diet with low H2S producing bacteria [11] and a plant-based diet in significantly altering the composition of the gut microbiome, increasing beneficial commensals in the gut, such as Bifidobacterium bifidum and Lactobacillus acidophilus , while reducing pathogenic Bacteroides fragilis and Clostridium perfringens [5]