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The plaques were smaller, less dense, and less numerous than in untreated mice, demonstrating the peptide's potential to mitigate amyloid-related toxicity

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Patients with gastroparesis, inflammatory bowel disease, or severe GERD require careful monitoring at higher doses

However, patients should not self-treat severe or persistent constipation without medical advice, especially if they develop pain, bloating, vomiting, inability to pass stool or gas, or rectal bleeding