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Therefore, lipedema surgery may be considered after a thorough evaluation and when other treatment options have failed, depending on the patient's specific situation

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Therapeutic strategies should aim not only to limit acute-phase injury and stabilize BBB integrity but also to modulate immune responses and support long-term repair mechanisms during the subacute and chronic stages

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In conclusion, the key phase to induce different effects of ECD with this model is the duration of the reoxygenation cycle