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Similarly, double-heterozygous-mutant worms carrying both the D72G and G247Vfs*6 alleles (modeling the two patients carrying the compound heterozygous variants) showed no embryonic lethality, even under prior starvation (Fig

These dynamic processes involve the bone multicellular unit composed of osteoblasts, osteoclasts, and osteocytes within bone matrix ( via MAPK and Wnt signaling pathways to promote Runx2 activity (56)

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