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Metformin Is Associated with a Lower Risk of Atrial Fibrillation and Ventricular Arrhythmias Compared with Sulfonylureas: An Observational Study

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It increases the risk for multiple metabolic complications including type 2 diabetes (T2D), metabolic-dysfunction associated steatotic liver disease (MASLD, previously known as non-alcoholic fatty liver disease), cardiovascular disease as well as many mechanical complications such as osteoarthritis and obstructive sleep apnoea (OSA) [3]

One of the cleaner ones, a 24-week randomized study of 279 mild-to-moderate Alzheimers patients, tested three doses against placebo and found a result no marketer would have designed: the lowest dose, 10 mL a day, beat placebo on both a cognitive scale and a global clinical rating, while the higher 30 and 60 mL doses improved the global rating but not cognition (Alvarez et al., Eur J Neurol 2006, randomized controlled trial)