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Smith says

Clin Chem Lab Med (2005) 43(4):3838

The most commonly reported side effects in retatrutide clinical trials have been gastrointestinal, including nausea, vomiting, diarrhea, constipation, abdominal discomfort, and decreased appetite

Because distinct ASGPR isoforms exhibit species-specific binding characteristics, specially glycans terminated with GalNac-2,6 sialic acid, pharmacokinetic and pharmacodynamic (PK/PD) data obtained in rodents may not accurately predict human outcomes