Your liver produces it in large quantities, and it serves two major functions that are directly relevant to hormonal health
in a vessel, dissolving the active ingredient, then adding any additional formulating agents, and stirring the mixture until complete dissolution is obtained
The sentence above, which is found in the primary article, would lead you to believe this, but if you dig through the 40-page supplementary information, you unearth this telling table: As you can see, the triglyceride, cholesterol, glucose and insulin levels of mice being fed normal chow are already pretty high (insulin levels at baseline convert to 16.3 microunits/ml)
S., NADPH Oxidase 4 (NOX4) as a Biomarker and Therapeutic Target in Neurodegenerative Diseases, Neural Regeneration Research 19 (2024): 19611966
KastinAJ,AkerstromV,PanW.Interactions of glucagon-like peptide-1 (GLP-1) with the bloodbrain barrier.J Mol Neurosci.2002;18:714