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And in some cases experts have seen the drug cause the enlargement of moles and freckles which can increase the risk of skin cancer

Indeed, the identification of juglone using this screen for an enzyme that has a high substrate Km from a relatively small library of just over 2000 compounds suggests that using this against larger, more complex libraries might yield additional hits against this important target enzyme

This synthesis process involves sequential catalysis by tyrosine hydroxylase (TH) and aromatic amino acid decarboxylase (AADC), which progressively convert tyrosine into dopamine (172)

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