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Akt/PkB activation can in turn increase PGC-1 levels (Fig

Crotonylation In 2011, lysine crotonylation (Kcr) was initially identified as a novel histone modification, using crotonyl-CoA as the donor substrate for crotonyltransferases to catalyze crotonyl group addition to histone lysine residues [61]

When blood glucose rises following a meal, GLP-1 agonists amplify the insulin response, facilitating glucose uptake by peripheral tissues and reducing postprandial hyperglycaemia