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But if left untreated, B12 deficiency can lead to problems with your brain, nerves or heart like: Fatigue Weakness Lightheadedness Headaches GI symptoms like nausea, gas, or diarrhea Memory loss, depression, or other mental issues Decreased smell and taste Vision changes Glossitis (painful, red, smooth tongue) Numbness, tingling, or muscle weakness Shortness of breath Heart palpitations One specific autoimmune disease that causes B12 deficiency is pernicious anemia

In addition, G6PD deficiencies are also classifiable by a variety of physicochemical parameters including chromatographic properties, thermostability, pH dependence, K M for glucose-6-phosphate, and K M for NADP +