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PubMed Central, Diz-Chaves, Yolanda, et al

Others find it harder because the novelty has worn off and the side effects feel more frustrating the second time

In addition to his diabetes, this patient was experiencing persistent, asymptomatic hyperkalemia

Needle anxiety is a real clinical variable, not a personal failing, and a provider who knows it is a barrier can work with you on that rather than around it

A landmark 2023 study published in JAMA found that GLP-1 agonist users experienced increased risks of gastrointestinal adverse events (with gastroparesis risk elevated compared to patients using other diabetes medications), while a 2024 case report in PMC documented the strong relationship between semaglutide use and gastroparesis symptoms that resolved only after drug discontinuation