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Several factors may hinder the absorption of natural food folate, e.g., partial release from the food matrix (incomplete liberation from cellular structures), destruction within the gastrointestinal tract, and incomplete hydrolysis of polyglutamates to monoglutamates (possibly mediated by partial inhibition of deconjugation enzymes by other dietary constituents such as organic acids)

Huwiler VV, Maissen-Abgottspon S, Stanga Z, Mhlebach S, Trepp R, Bally L et al (2024) Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

C., Regnier, C

Ongoing stress can interfere with hormonal signaling and limit the effectiveness of therapy

Effect of carbon dioxide on yeast growth and fermentation