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Commentary: The expanding benefits of GLP-1 medicines

This molecule, termed exendin-4, was found in the saliva of a lizard species known as the Heloderma suspectum

Alongside liraglutide, semaglutide has been shown to effectively improve motor impairments, rescue tyrosine hydroxylase (TH) levels, reduce -synuclein accumulation, chronic inflammation response in the brain and lipid peroxidation, inhibit mitochondrial mitophagy signaling and protect dopaminergic neurons in the substantia nigra and striatum in MPTP mouse models of PD [81]

The limited understanding of its role in GLP-1 regulation presents an opportunity to expand knowledge on non-nutrient-based modulators of incretin activity

When I counsel my patients, I tell them that the study sponsors have to escalate the dose monthly in clinical trials but that doesnt mean I have to practice medicine that way, Orandi explained to MNT