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[3] If the acidosis improves following N-acetylcysteine, this supports the diagnosis of pyroglutamic acidosis

The nucleophile provides the electrons to form the new bond and the pi bond of the carbonyl group is broken as it "gets out of the way." The electrons move from this pi bond onto what was the carbonyl oxygen

In plain English, the insulin seemed to have removed the barrier to carnitine uptake and there was now a way of manipulating muscle carnitine levels

Where whole-body healing meets modern medicine

It has been suggested that symptoms are more likely due to decreasing levels of oestrogen rather than low levels