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The key distinguishing features of lipoedema include: Symmetrical distribution of fat deposits, usually from hips to ankles Disproportionate appearance between upper and lower body Pain and tenderness in affected areas, often described as bruising easily Resistance to diet and exercise the affected tissue does not respond well to conventional weight loss methods Non-pitting tissue swelling and a feeling of heaviness in the legs Clinically, lipoedema differs from obesity in its pathophysiology